Berjalan kaki terasa lemah. Gejala sakit pinggang dan lemah otot kaki mulai membaik dari hari kehari. Hari ini Tgl 2 Januari adalah hari ke 12 setelah pengobatan. Fungsi ginjal tidak diperiksa selama sakit pinggang, dan sampai saat ini fungsi ginjal dan fungsi hati juga belum diperiksa. Jika Saudara adalah Ahli Farmakology, menurut Saudara, Apa yang akan terjadi pada saya jika pada malam ke 4 obat tidak dihentikan? Apakah kemungkinan saya akan mengalami kerusakan permanen pada otot atau organ lain seperti ginjal dan hati.
Sampai hari ini masih terasa telapak kaki sebelah kiri dekat kelingking jari kaki kiri masih terasa sedikit sakit jika dipijakkan. Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications.
If your doctor has recommended a dose different from the ones given here, do not change the way that you are taking the medication without consulting your doctor. Azithromycin must be taken for the recommended duration of treatment, even if you are feeling better. This will reduce the chances of having remaining bacteria grow back. The medication may be taken with or without food. Taking the medication with food may help to avoid stomach upset. It is important to take this medication exactly as prescribed by your doctor.
Finish all of this medication, even if you start to feel better. If you miss a dose, take it as soon as possible and continue on with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice. Serious adverse reactions included angioedema and cholestatic jaundice. Most of the adverse reactions leading to discontinuation were related to the gastrointestinal tract, e.
Palpitations and chest pain. Dyspepsia, flatulence, vomiting, melena, and cholestatic jaundice. Monilia, vaginitis, and nephritis. Dizziness, headache, vertigo, and somnolence. Rash, photosensitivity, and angioedema. Chronic therapy with mg weekly regimen The nature of adverse reactions seen with the mg weekly dosing regimen for the prevention of Mycobacterium avium infection in severely immunocompromised HIV-infected patients were similar to those seen with short-term dosing regimens.
Five percent of patients experienced reversible hearing impairment in the pivotal clinical trial for the treatment of disseminated MAC in patients with AIDS.
Hearing impairment has been reported with macrolide antibiotics, especially at higher doses. Discontinuations from treatment due to laboratory abnormalities or adverse reactions considered related to study drug occurred in 8 of 88 9.
Single 1 gram dose regimen Overall, the most common adverse reactions in patients receiving a single-dose regimen of 1 gram of azithromycin were related to the gastrointestinal system and were more frequently reported than in patients receiving the multiple-dose regimen. Post-marketing Experience The following adverse reactions have been identified during post approval use of azithromycin.
Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Arthralgia, edema, urticaria, and angioedema. Arrhythmias, including ventricular tachycardia, and hypotension. There have been reports of QT prolongation and torsades de pointes. Asthenia, paresthesia, fatigue, malaise, and anaphylaxis Genitourinary: Interstitial nephritis, acute renal failure, and vaginitis.
Abnormal liver function, hepatitis, cholestatic jaundice, hepatic necrosis, and hepatic failure, [see Warnings and Precautions 5. Aggressive reaction and anxiety. Laboratory Abnormalities Significant abnormalities irrespective of drug relationship occurring during the clinical trials were reported as follows: When follow-up was provided, changes in laboratory tests appeared to be reversible.
The suspension may be taken together with food. Some of these reactions with azithromycin have resulted in recurrent symptoms and required a longer period of observation and treatment. Since liver is the principal route of elimination for azithromycin, the use of azithromycin should be undertaken with caution in patients with significant hepatic disease. Cases of fulminant hepatitis potentially leading to life-threatening liver failure have been reported with azithromycin see section 4.
Some patients may have had pre-existing hepatic disease or may have been taking other hepatotoxic medicinal products. Azithromycin administration should be stopped if liver dysfunction has emerged. In patients receiving ergot derivatives, ergotism has been precipitated by co-administration of some macrolide antibiotics. There are no data concerning the possibility of an interaction between ergot and azithromycin. However, because of the theoretical possibility of ergotism, azithromycin and ergot derivatives should not be coadministered.
As with any antibiotic preparation, observation for signs of superinfection with non- susceptible organisms, including fungi is recommended.
Clostridium difficile associated diarrhoea CDAD has been reported with the use of nearly all antibacterial agents, including azithromycin, and may range in severity from mild diarrhoea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C.
Hypertoxin producing strains of C. CDAD must be considered in all patients who present with diarrhoea following antibiotic use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents. Prolonged cardiac repolarisation and QT interval, imparting a risk of developing cardiac arrhythmia and torsades de pointes, have been seen in treatment with macrolides including azithromycin see section 4.
Therefore as the following situations may lead to an increased risk for ventricular arrhythmias including torsade de pointes which can lead to cardiac arrest, azithromycin should be used with caution in patients with ongoing proarrhythmic conditions especially women and elderly patients such as patients: Safety and efficacy for the prevention or treatment of Mycobacterium avium complex in children have not been established.
The following should be considered before prescribing azithromycin: Azithromycin powder for oral solution is not suitable for treatment of severe infections where a high concentration of the antibiotic in the blood is rapidly needed.
In areas with a high incidence of erythromycin A resistance, it is especially important to take into consideration the evolution of the pattern of susceptibility to azithromycin and other antibiotics. This should be taken into account when treating infections caused by Streptococcus pneumoniae.
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